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KMID : 1123920090230020389
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 2 p.389 ~ p.396
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Study on the Mechanism of Vascular Relaxation of Ethanol Extract of Persicaria Perfoliata H. Gross
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Kim Hye-Yoom
Choi Byung-Sun
Jo Eun-Hee
Kang Dae-Gil
Lee Ho-Sub
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Abstract
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The ethanol extract of Persicaria perfoliata (EPP) induced relaxation of the phenylephrine-precontracted aorta in a dose-dependent manner, which was abolished by removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4}-oxadiazole-[4,3-)-quinixalin-1-one (ODQ) inhibited the relaxation induced by EPP. However, EPP-induced relaxation was not blocked by pretreatment with indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, or propranolol. Incubation of endothelium-intact thoracic aortic ring with EPP increased the production of cGMP, which was also blocked by pretreatment with L-NAME or ODQ. These results suggest that EPP dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.
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KEYWORD
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ethanol extract of Persicaria perfoliata (EPP), aortic tissues, endothelium, nitric oxide/cGMP, vascular relaxation
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